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Biophotonics applies photonics technology to the fields of medicine, biology and biotechnology. Basic research and innovation in photonics that is very fundamental in science and engineering is needed to lay the foundation for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies. Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key goals.

Examples of topics are:

* Macromolecule Markers - Innovative methods for labeling of macromolecules, new compositions of matter/methods of fabrication of multi-color probes such as might be used for marking and detection of specific pathological cells and push the envelope of optical sensing to the limits of detection, resolution, and identification

* Low Coherence Sensing at the Nanoscale - Low coherence enhanced backscattering (LEBS), n-dimensional elastic light scattering, and angle-resolved low coherence interferometry for early cancer detection (dysplasia)

* Neurophotonics - Studies of photon activation of neurons at the interface of nanomaterials attached to cells. Development and application of biocompatible photonic tools such as parallel interfaces and interconnects for communicating and control of neural networks

* Micro- and Nano-photonic - Development and application of nanoparticle fluorescent quantum-dots; sensitive, multiplexed, high-throughput characterization of macromolecular properties of cells; nanomaterials and nanodevices for biomedicine

* Optogenetics - Employing light-activated channels and enzymes for manipulation of neural activity with temporal precision.

The duration of unsolicited awards is generally one to three years. The average annual award size for the program is $100,000 for individual investigators and $200,000 for multiple investigators. Proposals requesting a substantially higher amount than this, without prior consultation with the Program Director, may be returned without review.

Innovative proposals outside of these specific interest areas can be considered. However, prior to submission, it is recommended that the PI contact the Program Director to avoid the possibility of the proposal being returned without review.

website: http://www.nsf.gov/funding/pgm_summ.jsp?pims_id=501025&org=NSF&sel_org=NSF&from=fund